Assay Detail
Binding
CHEMBL5524536
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Inhibition of PTPN2 in IFN-gamma induced mouse B16-F10 cells
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | B16-F10 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity optimization of azepane-containing derivatives as PTPN2/PTPN1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.31 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5095164 | OSUNPROTAFIB | 2.0 | 1 | 7.36 |
| CHEMBL5564604 | — | — | 1 | 6.93 |
| CHEMBL5559660 | — | — | 1 | 6.67 |
| CHEMBL5557812 | — | — | 1 | 6.61 |
| CHEMBL5561163 | — | — | 2 | 6.56 |
| CHEMBL5562456 | — | — | 1 | 6.46 |
| CHEMBL5564299 | — | — | 1 | 6.42 |
| CHEMBL5559694 | — | — | 1 | 6.40 |
| CHEMBL5560433 | — | — | 1 | 6.37 |
| CHEMBL5562964 | — | — | 1 | 6.34 |
| CHEMBL5567463 | — | — | 1 | 6.17 |
| CHEMBL5561180 | — | — | 1 | 5.99 |
| CHEMBL5561962 | — | — | 1 | 5.27 |
| CHEMBL5561290 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5095164 | OSUNPROTAFIB | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL5564604 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL5559660 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL5557812 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL5561163 | — | IC50 | = | 276.0 | nM | 6.56 |
| CHEMBL5562456 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL5564299 | — | IC50 | = | 378.0 | nM | 6.42 |
| CHEMBL5559694 | — | IC50 | = | 399.0 | nM | 6.40 |
| CHEMBL5560433 | — | IC50 | = | 425.0 | nM | 6.37 |
| CHEMBL5562964 | — | IC50 | = | 461.0 | nM | 6.34 |
| CHEMBL5561163 | — | IC50 | = | 455.0 | nM | 6.34 |
| CHEMBL5567463 | — | IC50 | = | 669.0 | nM | 6.17 |
| CHEMBL5561180 | — | IC50 | = | 1033.0 | nM | 5.99 |
| CHEMBL5561962 | — | IC50 | = | 5332.0 | nM | 5.27 |
| CHEMBL5561290 | — | IC50 | = | 17739.0 | nM | 4.75 |