Assay Detail
Binding
CHEMBL5524581
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Wnt/beta-catenin signalling in HEK293 cells assessed as reduction in luciferase activity incubated for 24 hrs by TOPFlash luciferase reporter assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Modulators for palmitoylation of proteins and small molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.37 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5568162 | — | — | 1 | 8.00 |
| CHEMBL1581616 | — | — | 1 | 7.82 |
| CHEMBL5559896 | — | — | 1 | 7.80 |
| CHEMBL5565801 | — | — | 1 | 7.60 |
| CHEMBL1257064 | — | — | 1 | 7.55 |
| CHEMBL5561487 | — | — | 1 | 7.40 |
| CHEMBL1257063 | — | — | 1 | 7.24 |
| CHEMBL5559241 | — | — | 1 | 7.13 |
| CHEMBL1484698 | — | — | 1 | 7.05 |
| CHEMBL5567998 | — | — | 1 | 6.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5568162 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1581616 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5559896 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5565801 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1257064 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5561487 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1257063 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL5559241 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL1484698 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5567998 | — | IC50 | = | 710.0 | nM | 6.15 |