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Assay Detail

CHEMBL5524593

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of SPTLC2 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Serine palmitoyltransferase 2 (CHEMBL1250344)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Modulators for palmitoylation of proteins and small molecules.
Fan Z, Hao Y, Huo Y, Cao F, Li L, Xu J, Song Y, Yang K.
Eur J Med Chem (2024) 271 : 116408 -116408
PubMed 38621327 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 4 9.28 9.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5561881 1 9.62
CHEMBL4228472 1 9.29
CHEMBL4225519 1 9.12
CHEMBL5565596 1 9.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5561881 IC50 = 0.24 nM 9.62
CHEMBL4228472 IC50 = 0.51 nM 9.29
CHEMBL4225519 IC50 = 0.76 nM 9.12
CHEMBL5565596 IC50 = 0.8 nM 9.10