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Assay Detail

CHEMBL5524640

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of N-terminal His-tagged mouse GOAT expressed in baculovirus infected insect cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Ghrelin O-acyltransferase (CHEMBL1255134)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Modulators for palmitoylation of proteins and small molecules.
Fan Z, Hao Y, Huo Y, Cao F, Li L, Xu J, Song Y, Yang K.
Eur J Med Chem (2024) 271 : 116408 -116408
PubMed 38621327 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 4 5.47 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5556384 1 6.70
CHEMBL5559872 1 5.16
CHEMBL5542716 1 5.12
CHEMBL5563229 1 4.88

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5556384 IC50 = 200.0 nM 6.70
CHEMBL5559872 IC50 = 7000.0 nM 5.16
CHEMBL5542716 IC50 = 7540.0 nM 5.12
CHEMBL5563229 IC50 = 13100.0 nM 4.88