Assay Detail
Binding
CHEMBL5524644
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Inhibition of human recombinant COX-2 by EIA method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploration of isoxazole analogs: Synthesis, COX inhibition, anticancer screening, 3D multicellular tumor spheroids, and molecular modeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.31 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 7.55 |
| CHEMBL571 | KETOPROFEN | 4.0 | 1 | 6.79 |
| CHEMBL5561700 | — | — | 1 | 6.61 |
| CHEMBL600662 | — | — | 1 | 6.58 |
| CHEMBL5558069 | — | — | 1 | 6.52 |
| CHEMBL5562199 | — | — | 1 | 6.31 |
| CHEMBL5532591 | — | — | 1 | 6.28 |
| CHEMBL5558625 | — | — | 1 | 6.22 |
| CHEMBL5561303 | — | — | 1 | 6.14 |
| CHEMBL5562342 | — | — | 1 | 5.92 |
| CHEMBL5566103 | — | — | 1 | 5.88 |
| CHEMBL5532578 | — | — | 1 | 5.82 |
| CHEMBL5567935 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL571 | KETOPROFEN | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL5561700 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL600662 | — | IC50 | = | 264.0 | nM | 6.58 |
| CHEMBL5558069 | — | IC50 | = | 301.0 | nM | 6.52 |
| CHEMBL5562199 | — | IC50 | = | 493.0 | nM | 6.31 |
| CHEMBL5532591 | — | IC50 | = | 529.0 | nM | 6.28 |
| CHEMBL5558625 | — | IC50 | = | 597.0 | nM | 6.22 |
| CHEMBL5561303 | — | IC50 | = | 729.0 | nM | 6.14 |
| CHEMBL5562342 | — | IC50 | = | 1188.0 | nM | 5.92 |
| CHEMBL5566103 | — | IC50 | = | 1303.0 | nM | 5.88 |
| CHEMBL5532578 | — | IC50 | = | 1522.0 | nM | 5.82 |
| CHEMBL5567935 | — | IC50 | = | 3463.0 | nM | 5.46 |