Assay Detail
Toxicity
CHEMBL5524652
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Antiproliferative activity against human LX2 cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | LX-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploration of isoxazole analogs: Synthesis, COX inhibition, anticancer screening, 3D multicellular tumor spheroids, and molecular modeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.28 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 6.75 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.68 |
| CHEMBL5561700 | — | — | 1 | 4.70 |
| CHEMBL600662 | — | — | 1 | 4.27 |
| CHEMBL5567935 | — | — | 1 | 4.00 |
| CHEMBL5558069 | — | — | 1 | - |
| CHEMBL5562199 | — | — | 1 | - |
| CHEMBL5532578 | — | — | 1 | - |
| CHEMBL5558625 | — | — | 1 | - |
| CHEMBL5562342 | — | — | 1 | - |
| CHEMBL5561303 | — | — | 1 | - |
| CHEMBL5532591 | — | — | 1 | - |
| CHEMBL5566103 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5561700 | — | IC50 | = | 20010.0 | nM | 4.70 |
| CHEMBL600662 | — | IC50 | = | 53690.0 | nM | 4.27 |
| CHEMBL5567935 | — | IC50 | = | 99880.0 | nM | 4.00 |
| CHEMBL5558069 | — | IC50 | = | 266490.0 | nM | - |
| CHEMBL5562199 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL5532578 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL5558625 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL5562342 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL5561303 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL5532591 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL5566103 | — | IC50 | > | 300000.0 | nM | - |