Assay Detail
Functional
CHEMBL5524781
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel tubulin-targeting agents with a dual-mechanism for polymerization inhibition and protein degradation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 50 | 6.75 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.92 |
| CHEMBL571546 | TIRBANIBULIN | 4.0 | 1 | 7.55 |
| CHEMBL5557336 | — | — | 1 | 7.51 |
| CHEMBL5542991 | — | — | 1 | 7.50 |
| CHEMBL5562653 | — | — | 1 | 7.46 |
| CHEMBL5559839 | — | — | 1 | 7.24 |
| CHEMBL5558994 | — | — | 1 | 7.21 |
| CHEMBL5561029 | — | — | 1 | 7.19 |
| CHEMBL5562799 | — | — | 1 | 7.17 |
| CHEMBL5568599 | — | — | 1 | 7.14 |
| CHEMBL5568161 | — | — | 1 | 7.12 |
| CHEMBL5555439 | — | — | 1 | 7.11 |
| CHEMBL5568552 | — | — | 1 | 7.08 |
| CHEMBL5557320 | — | — | 1 | 7.06 |
| CHEMBL5561915 | — | — | 1 | 7.00 |
| CHEMBL5562995 | — | — | 1 | 6.98 |
| CHEMBL5565279 | — | — | 1 | 6.97 |
| CHEMBL5567596 | — | — | 1 | 6.95 |
| CHEMBL5567137 | — | — | 1 | 6.95 |
| CHEMBL5563089 | — | — | 1 | 6.94 |
| CHEMBL5561183 | — | — | 1 | 6.92 |
| CHEMBL5560880 | — | — | 1 | 6.91 |
| CHEMBL5560863 | — | — | 1 | 6.89 |
| CHEMBL5565111 | — | — | 1 | 6.86 |
| CHEMBL5561749 | — | — | 1 | 6.84 |
| CHEMBL5568108 | — | — | 1 | 6.79 |
| CHEMBL5562790 | — | — | 1 | 6.75 |
| CHEMBL5558377 | — | — | 1 | 6.65 |
| CHEMBL5557358 | — | — | 1 | 6.64 |
| CHEMBL5566138 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL571546 | TIRBANIBULIN | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5557336 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5542991 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5562653 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5559839 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL5558994 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL5561029 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL5562799 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5568599 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL5568161 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL5555439 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL5568552 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL5557320 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL5561915 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL5562995 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL5565279 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL5567596 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL5567137 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL5563089 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL5561183 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5560880 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL5560863 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL5565111 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL5561749 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL5568108 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL5562790 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5558377 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL5557358 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL5566138 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL5568001 | — | IC50 | = | 255.0 | nM | 6.59 |
| CHEMBL5542456 | — | IC50 | = | 256.0 | nM | 6.59 |
| CHEMBL5563891 | — | IC50 | = | 307.0 | nM | 6.51 |
| CHEMBL5563799 | — | IC50 | = | 323.0 | nM | 6.49 |
| CHEMBL5565346 | — | IC50 | = | 353.0 | nM | 6.45 |
| CHEMBL5542696 | — | IC50 | = | 365.0 | nM | 6.44 |
| CHEMBL5561833 | — | IC50 | = | 364.0 | nM | 6.44 |
| CHEMBL5563170 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5555153 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5568387 | — | IC50 | = | 464.0 | nM | 6.33 |
| CHEMBL5567211 | — | IC50 | = | 503.0 | nM | 6.30 |
| CHEMBL5565110 | — | IC50 | = | 573.0 | nM | 6.24 |
| CHEMBL5567269 | — | IC50 | = | 591.0 | nM | 6.23 |
| CHEMBL5568598 | — | IC50 | = | 601.0 | nM | 6.22 |
| CHEMBL5542453 | — | IC50 | = | 663.0 | nM | 6.18 |
| CHEMBL5567415 | — | IC50 | = | 781.0 | nM | 6.11 |
| CHEMBL5559221 | — | IC50 | = | 946.0 | nM | 6.02 |
| CHEMBL5565661 | — | IC50 | = | 1027.0 | nM | 5.99 |
| CHEMBL5562464 | — | IC50 | = | 1402.0 | nM | 5.85 |
| CHEMBL5565706 | — | IC50 | = | 2324.0 | nM | 5.63 |