Assay Detail
Binding
CHEMBL5524869
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild-type FGFR2 (458 to 765 residues)(unknown origin) expressed in Escherichia coli using FLPeptide30 as substrate preincubated for 30 mins followed by ATP addition measured after 90 mins
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of LHQ490 as a highly selective fibroblast growth factor receptor 2 (FGFR2) inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.52 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5314555 | LIRAFUGRATINIB | 2.0 | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5314555 | LIRAFUGRATINIB | IC50 | = | 3.0 | nM | 8.52 |