Assay Detail
Functional
CHEMBL5524893
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Antiproliferation activity against human KATO III cells harboring FGFR2 amplification incubated for 72 hrs by CCK8 assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KATO III |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of LHQ490 as a highly selective fibroblast growth factor receptor 2 (FGFR2) inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.24 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297522 | PEMIGATINIB | 4.0 | 1 | 8.51 |
| CHEMBL5542292 | — | — | 1 | 7.82 |
| CHEMBL5564803 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297522 | PEMIGATINIB | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL5542292 | — | IC50 | = | 15.1 | nM | 7.82 |
| CHEMBL5564803 | — | IC50 | = | 3963.0 | nM | 5.40 |