Assay Detail
Functional
CHEMBL5525210
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Antiproliferation activity against human MCF7/ADR cells measured after 72 hrs incubation by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI/ADR-RES |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship study of new carbazole sulfonamide derivatives as anticancer agents with dual-target mechanism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.63 | 8.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5562657 | — | — | 1 | 8.73 |
| CHEMBL5560979 | — | — | 1 | 8.12 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 7.90 |
| CHEMBL3939038 | — | — | 1 | 7.05 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5562657 | — | IC50 | = | 1.86 | nM | 8.73 |
| CHEMBL5560979 | — | IC50 | = | 7.56 | nM | 8.12 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 12.47 | nM | 7.90 |
| CHEMBL3939038 | — | IC50 | = | 88.19 | nM | 7.05 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 463.86 | nM | 6.33 |