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Assay Detail

CHEMBL5525280

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human OCI-AML2 cells incubated for 48 hrs by MTS assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type OCI-AML2
Confidence 1 — Organism
Curated By Autocuration

Target

OCI-AML2 (CHEMBL2366220)
Type CELL-LINE
Organism Homo sapiens

Publication

Identification of novel GSPT1 degraders by virtual screening and bioassay.
Zhang S, Nie S, Ma G, Shen M, Kong L, Zuo Z, Li Y.
Eur J Med Chem (2024) 273 : 116524 -116524
PubMed 38795517 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.49 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4742712 1 8.00
CHEMBL5566691 1 5.60
CHEMBL5566579 1 5.58
CHEMBL5561572 1 5.58
CHEMBL2000584 1 5.57
CHEMBL5560999 1 5.05
CHEMBL5542599 1 4.98
CHEMBL5568165 1 4.96
CHEMBL3208197 1 4.81
CHEMBL5560535 1 4.77
CHEMBL5566890 1 -
CHEMBL3214424 1 -
CHEMBL5556820 1 -
CHEMBL5555117 1 -
CHEMBL5559758 1 -
CHEMBL3195690 1 -
CHEMBL5561994 1 -
CHEMBL5562054 1 -
CHEMBL5568413 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4742712 IC50 = 10.0 nM 8.00
CHEMBL5566691 IC50 = 2490.0 nM 5.60
CHEMBL5566579 IC50 = 2640.0 nM 5.58
CHEMBL5561572 IC50 = 2660.0 nM 5.58
CHEMBL2000584 IC50 = 2680.0 nM 5.57
CHEMBL5560999 IC50 = 8980.0 nM 5.05
CHEMBL5542599 IC50 = 10420.0 nM 4.98
CHEMBL5568165 IC50 = 11020.0 nM 4.96
CHEMBL3208197 IC50 = 15570.0 nM 4.81
CHEMBL5560535 IC50 = 17150.0 nM 4.77
CHEMBL5566890 IC50 > 40000.0 nM -
CHEMBL3214424 IC50 > 40000.0 nM -
CHEMBL5556820 IC50 > 40000.0 nM -
CHEMBL5555117 IC50 > 40000.0 nM -
CHEMBL5559758 IC50 > 40000.0 nM -
CHEMBL3195690 IC50 > 40000.0 nM -
CHEMBL5561994 IC50 > 40000.0 nM -
CHEMBL5562054 IC50 > 40000.0 nM -
CHEMBL5568413 IC50 > 40000.0 nM -