Assay Detail
Binding
CHEMBL5525372
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of candida albicans CYP51 14alpha demethylase activity incubated for 30 mins by HPLC analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Candida albicans |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Lanosterol 14-alpha demethylase (CHEMBL1780) ↗| Type | SINGLE PROTEIN |
| Organism | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
Publication
Design, Synthesis, and Activity Evaluation of Novel Benzazole Bifunctional Antifungal Inhibitors with an LDH Carrier.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.84 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL106 | FLUCONAZOLE | 4.0 | 1 | 7.01 |
| CHEMBL5562102 | — | — | 1 | 6.95 |
| CHEMBL5561168 | — | — | 1 | 6.80 |
| CHEMBL5566404 | — | — | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL106 | FLUCONAZOLE | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL5562102 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL5561168 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL5566404 | — | IC50 | = | 256.0 | nM | 6.59 |