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Assay Detail

CHEMBL5525966

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of PPM1A (unknown origin)
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Protein phosphatase 1A (CHEMBL2437)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Small Molecule Targeting PPM1A Activates Autophagy for <i>Mycobacterium tuberculosis</i> Host-Directed Therapy.
Yu Z, Liang YC, Berton S, Liu L, Zou J, Chen L, Xu Z, Luo C, Sun J, Yang W.
J Med Chem (2024) 67 : 11917 -11936
PubMed 38958057 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.92 5.92
Ki 1 6.08 6.08

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5566508 2 6.08

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5566508 Ki = 840.0 nM 6.08
CHEMBL5566508 IC50 = 1190.0 nM 5.92