Assay Detail
Binding
CHEMBL5525967
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human PPM1A using pNPP as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by absorbance based assay
39
Total Activities
38
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Small Molecule Targeting PPM1A Activates Autophagy for <i>Mycobacterium tuberculosis</i> Host-Directed Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.82 | 6.75 |
| Ki | 1 | 6.23 | 6.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5566601 | — | — | 2 | 6.75 |
| CHEMBL5556587 | — | — | 1 | 6.54 |
| CHEMBL5566508 | — | — | 1 | 5.92 |
| CHEMBL5566557 | — | — | 1 | 5.84 |
| CHEMBL5563947 | — | — | 1 | 5.58 |
| CHEMBL5565791 | — | — | 1 | 5.51 |
| CHEMBL5562841 | — | — | 1 | 5.45 |
| CHEMBL5561304 | — | — | 1 | 5.43 |
| CHEMBL5563155 | — | — | 1 | 5.35 |
| CHEMBL5565057 | — | — | 1 | - |
| CHEMBL5563257 | — | — | 1 | - |
| CHEMBL5563035 | — | — | 1 | - |
| CHEMBL5564636 | — | — | 1 | - |
| CHEMBL5560349 | — | — | 1 | - |
| CHEMBL5564351 | — | — | 1 | - |
| CHEMBL5561842 | — | — | 1 | - |
| CHEMBL5566677 | — | — | 1 | - |
| CHEMBL5559748 | — | — | 1 | - |
| CHEMBL5561102 | — | — | 1 | - |
| CHEMBL5564902 | — | — | 1 | - |
| CHEMBL5563341 | — | — | 1 | - |
| CHEMBL5542315 | — | — | 1 | - |
| CHEMBL5560287 | — | — | 1 | - |
| CHEMBL5555447 | — | — | 1 | - |
| CHEMBL5562300 | — | — | 1 | - |
| CHEMBL5562250 | — | — | 1 | - |
| CHEMBL5562106 | — | — | 1 | - |
| CHEMBL5568416 | — | — | 1 | - |
| CHEMBL5564735 | — | — | 1 | - |
| CHEMBL5562047 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5566601 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5556587 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5566601 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL5566508 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL5566557 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL5563947 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5565791 | — | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL5562841 | — | IC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL5561304 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL5563155 | — | IC50 | = | 4510.0 | nM | 5.35 |
| CHEMBL5560349 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5568331 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5564351 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5561842 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5566677 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5559748 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5561102 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5557318 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5564765 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5555842 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5567418 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5564107 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5566262 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5558100 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5564636 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5563035 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5563257 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5565057 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5564902 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5563341 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5542315 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5560287 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5555447 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5562300 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5562250 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5562106 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5568416 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5562047 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5564735 | — | IC50 | > | 20000.0 | nM | - |