Assay Detail
Functional
CHEMBL5526574
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Diaryl-Substituted Fused Heterocycles Targeting Katanin and Tubulin with Potent Antitumor and Antimultidrug Resistance Efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 7.29 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5560224 | — | — | 1 | 9.00 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.52 |
| CHEMBL5542472 | — | — | 1 | 8.52 |
| CHEMBL5565133 | — | — | 1 | 8.30 |
| CHEMBL5557172 | — | — | 1 | 8.10 |
| CHEMBL5565704 | — | — | 1 | 8.05 |
| CHEMBL5561214 | — | — | 1 | 7.92 |
| CHEMBL5559769 | — | — | 1 | 7.85 |
| CHEMBL5561661 | — | — | 1 | 7.62 |
| CHEMBL5562210 | — | — | 1 | 7.62 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.60 |
| CHEMBL5568337 | — | — | 1 | 7.58 |
| CHEMBL5505836 | — | — | 1 | 7.57 |
| CHEMBL5542835 | — | — | 1 | 7.50 |
| CHEMBL5555063 | — | — | 1 | 7.50 |
| CHEMBL5568371 | — | — | 1 | 7.48 |
| CHEMBL5083575 | — | — | 1 | 7.44 |
| CHEMBL5567310 | — | — | 1 | 7.38 |
| CHEMBL5557076 | — | — | 1 | 7.17 |
| CHEMBL5565765 | — | — | 1 | 7.08 |
| CHEMBL5564528 | — | — | 1 | 7.06 |
| CHEMBL5555470 | — | — | 1 | 6.93 |
| CHEMBL5561000 | — | — | 1 | 6.92 |
| CHEMBL5560244 | — | — | 1 | 6.68 |
| CHEMBL5562576 | — | — | 1 | 6.64 |
| CHEMBL5563318 | — | — | 1 | 6.59 |
| CHEMBL5563718 | — | — | 1 | 6.58 |
| CHEMBL5561448 | — | — | 1 | 6.57 |
| CHEMBL5567608 | — | — | 1 | 6.44 |
| CHEMBL5556817 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5560224 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5542472 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5565133 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5557172 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5565704 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5561214 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5559769 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5561661 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5562210 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL107 | COLCHICINE | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5568337 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5505836 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5542835 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5555063 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5568371 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL5083575 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5567310 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL5557076 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5565765 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL5564528 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL5555470 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL5561000 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL5560244 | — | IC50 | = | 211.0 | nM | 6.68 |
| CHEMBL5562576 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL5563318 | — | IC50 | = | 256.0 | nM | 6.59 |
| CHEMBL5563718 | — | IC50 | = | 266.0 | nM | 6.58 |
| CHEMBL5561448 | — | IC50 | = | 267.0 | nM | 6.57 |
| CHEMBL5567608 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5556817 | — | IC50 | = | 368.0 | nM | 6.43 |
| CHEMBL4448067 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL5558404 | — | IC50 | = | 433.0 | nM | 6.36 |
| CHEMBL4466747 | — | IC50 | = | 598.0 | nM | 6.22 |
| CHEMBL4561563 | — | IC50 | = | 813.0 | nM | 6.09 |
| CHEMBL5568415 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5555138 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5565800 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5565762 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5560957 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5560259 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5567689 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5563522 | — | IC50 | > | 1000.0 | nM | - |