Assay Detail
Binding
CHEMBL5526754
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal 6xHis tagged human Hsp70 expressed in Escherichia coli BL21 (DE3)/FAM-labeled BimBH3 peptide (unknown origin) protein protein interaction incubated for 10 mins by fluorescence polarization assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Biphenyl Derivatives to Target Hsp70-Bim Protein-Protein Interaction in Chronic Myeloid Leukemia by Scaffold Hopping Strategy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.10 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5555840 | — | — | 1 | 7.16 |
| CHEMBL5564252 | — | — | 1 | 7.05 |
| CHEMBL5559278 | — | — | 1 | 6.55 |
| CHEMBL5564322 | — | — | 1 | 6.48 |
| CHEMBL5559963 | — | — | 1 | 6.39 |
| CHEMBL5562172 | — | — | 1 | 6.21 |
| CHEMBL5397919 | — | — | 1 | 6.10 |
| CHEMBL5565321 | — | — | 1 | 6.09 |
| CHEMBL5563022 | — | — | 1 | 6.06 |
| CHEMBL5561641 | — | — | 1 | 6.03 |
| CHEMBL5562439 | — | — | 1 | 5.67 |
| CHEMBL5565355 | — | — | 1 | 5.44 |
| CHEMBL5561415 | — | — | 1 | 5.09 |
| CHEMBL5542768 | — | — | 1 | 5.06 |
| CHEMBL5562006 | — | — | 1 | - |
| CHEMBL5568002 | — | — | 1 | - |
| CHEMBL5560223 | — | — | 1 | - |
| CHEMBL5567472 | — | — | 1 | - |
| CHEMBL5565964 | — | — | 1 | - |
| CHEMBL5565577 | — | — | 1 | - |
| CHEMBL5555383 | — | — | 1 | - |
| CHEMBL5563334 | — | — | 1 | - |
| CHEMBL5542337 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5555840 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5564252 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5559278 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5564322 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL5559963 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL5562172 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL5397919 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5565321 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL5563022 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL5561641 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL5562439 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL5565355 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL5561415 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL5542768 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL5562006 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5568002 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5560223 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5567472 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5565964 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5565577 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5555383 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5563334 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5542337 | — | IC50 | > | 10000.0 | nM | - |