Assay Detail
Binding
CHEMBL5526756
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to N-terminal 6xHis tagged human HSP70 expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by ITC analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Biphenyl Derivatives to Target Hsp70-Bim Protein-Protein Interaction in Chronic Myeloid Leukemia by Scaffold Hopping Strategy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 6.54 | 6.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5555840 | — | — | 1 | 6.91 |
| CHEMBL5397919 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5555840 | — | Kd | = | 123.0 | nM | 6.91 |
| CHEMBL5397919 | — | Kd | = | 688.0 | nM | 6.16 |