Assay Detail
Functional
CHEMBL5526759
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of apoptosis in human BV-173 cells incubated for 48 hrs by Annexin V-FITC staining based flow cytometry analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BV-173 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Biphenyl Derivatives to Target Hsp70-Bim Protein-Protein Interaction in Chronic Myeloid Leukemia by Scaffold Hopping Strategy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.93 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5555840 | — | — | 1 | 6.37 |
| CHEMBL5397919 | — | — | 1 | 6.18 |
| CHEMBL470334 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5555840 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5397919 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL470334 | — | EC50 | = | 5640.0 | nM | 5.25 |