Assay Detail
Binding
CHEMBL5527103
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Binding affinity to D5 receptor (unknown origin) assessed as inhibition constant
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Natural Product-Inspired Dopamine Receptor Ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.46 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL487387 | STEPHOLIDINE | — | 1 | 8.24 |
| CHEMBL2334891 | — | — | 1 | 8.02 |
| CHEMBL1962947 | — | — | 1 | 7.98 |
| CHEMBL5563974 | — | — | 1 | 7.87 |
| CHEMBL726 | FLUPHENAZINE | 4.0 | 1 | 7.68 |
| CHEMBL1621 | PALIPERIDONE | 4.0 | 1 | 7.54 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 6.83 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 6.64 |
| CHEMBL4637246 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL487387 | STEPHOLIDINE | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL2334891 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL1962947 | — | Ki | = | 10.5 | nM | 7.98 |
| CHEMBL5563974 | — | Ki | = | 13.4 | nM | 7.87 |
| CHEMBL726 | FLUPHENAZINE | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL1621 | PALIPERIDONE | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 147.0 | nM | 6.83 |
| CHEMBL59 | DOPAMINE | Ki | = | 228.0 | nM | 6.64 |
| CHEMBL4637246 | — | Ki | = | 418.0 | nM | 6.38 |