Assay Detail
Binding
CHEMBL5527105
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Binding affinity to D2 receptor (unknown origin) assessed as inhibition constant
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Natural Product-Inspired Dopamine Receptor Ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 7.61 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157138 | LISURIDE | 3.0 | 1 | 9.52 |
| CHEMBL1201087 | CABERGOLINE | 4.0 | 1 | 9.44 |
| CHEMBL726 | FLUPHENAZINE | 4.0 | 1 | 8.84 |
| CHEMBL1621 | PALIPERIDONE | 4.0 | 1 | 8.80 |
| CHEMBL531 | PERGOLIDE | 4.0 | 1 | 8.40 |
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | — | 1 | 8.00 |
| CHEMBL493 | BROMOCRIPTINE | 4.0 | 1 | 8.00 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.98 |
| CHEMBL487387 | STEPHOLIDINE | — | 1 | 7.94 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 7.90 |
| CHEMBL27559 | — | — | 1 | 7.54 |
| CHEMBL2334891 | — | — | 1 | 7.38 |
| CHEMBL405345 | — | — | 1 | 7.36 |
| CHEMBL255229 | — | — | 1 | 7.14 |
| CHEMBL4637246 | — | — | 1 | 6.64 |
| CHEMBL403550 | — | — | 1 | 6.47 |
| CHEMBL487182 | TETRAHYDROPALMATINE | 2.0 | 1 | 6.41 |
| CHEMBL1672309 | — | — | 1 | 6.31 |
| CHEMBL1672312 | — | — | 1 | 6.12 |
| CHEMBL4633772 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157138 | LISURIDE | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL1201087 | CABERGOLINE | Ki | = | 0.36 | nM | 9.44 |
| CHEMBL726 | FLUPHENAZINE | Ki | = | 1.44 | nM | 8.84 |
| CHEMBL1621 | PALIPERIDONE | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL531 | PERGOLIDE | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL493 | BROMOCRIPTINE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 10.4 | nM | 7.98 |
| CHEMBL487387 | STEPHOLIDINE | Ki | = | 11.6 | nM | 7.94 |
| CHEMBL59 | DOPAMINE | Ki | = | 12.5 | nM | 7.90 |
| CHEMBL27559 | — | Ki | = | 28.5 | nM | 7.54 |
| CHEMBL2334891 | — | Ki | = | 41.8 | nM | 7.38 |
| CHEMBL405345 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL255229 | — | Ki | = | 72.3 | nM | 7.14 |
| CHEMBL4637246 | — | Ki | = | 231.0 | nM | 6.64 |
| CHEMBL403550 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL487182 | TETRAHYDROPALMATINE | Ki | = | 388.0 | nM | 6.41 |
| CHEMBL1672309 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL1672312 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL4633772 | — | Ki | = | 854.0 | nM | 6.07 |