Assay Detail
Binding
CHEMBL5527106
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Binding affinity to D3 receptor (unknown origin) assessed as inhibition constant
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Natural Product-Inspired Dopamine Receptor Ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.50 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157138 | LISURIDE | 3.0 | 1 | 8.77 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 8.52 |
| CHEMBL726 | FLUPHENAZINE | 4.0 | 1 | 8.49 |
| CHEMBL531 | PERGOLIDE | 4.0 | 1 | 8.40 |
| CHEMBL1621 | PALIPERIDONE | 4.0 | 1 | 8.12 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.69 |
| CHEMBL487387 | STEPHOLIDINE | — | 1 | 7.63 |
| CHEMBL2334891 | — | — | 1 | 7.43 |
| CHEMBL493 | BROMOCRIPTINE | 4.0 | 1 | 7.06 |
| CHEMBL2425376 | — | — | 1 | 7.03 |
| CHEMBL1962947 | — | — | 1 | 6.26 |
| CHEMBL5563974 | — | — | 1 | 6.22 |
| CHEMBL487182 | TETRAHYDROPALMATINE | 2.0 | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157138 | LISURIDE | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL59 | DOPAMINE | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL726 | FLUPHENAZINE | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL531 | PERGOLIDE | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL1621 | PALIPERIDONE | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 20.5 | nM | 7.69 |
| CHEMBL487387 | STEPHOLIDINE | Ki | = | 23.4 | nM | 7.63 |
| CHEMBL2334891 | — | Ki | = | 37.3 | nM | 7.43 |
| CHEMBL493 | BROMOCRIPTINE | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL2425376 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL1962947 | — | Ki | = | 548.0 | nM | 6.26 |
| CHEMBL5563974 | — | Ki | = | 606.0 | nM | 6.22 |
| CHEMBL487182 | TETRAHYDROPALMATINE | Ki | = | 1420.0 | nM | 5.85 |