Assay Detail
Binding
CHEMBL5527107
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Binding affinity to D4 receptor (unknown origin) assessed as inhibition constant
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Natural Product-Inspired Dopamine Receptor Ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.34 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157138 | LISURIDE | 3.0 | 1 | 8.49 |
| CHEMBL531 | PERGOLIDE | 4.0 | 1 | 8.21 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 8.19 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.52 |
| CHEMBL1621 | PALIPERIDONE | 4.0 | 1 | 7.42 |
| CHEMBL2334891 | — | — | 1 | 7.11 |
| CHEMBL726 | FLUPHENAZINE | 4.0 | 1 | 6.89 |
| CHEMBL493 | BROMOCRIPTINE | 4.0 | 1 | 6.43 |
| CHEMBL487387 | STEPHOLIDINE | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157138 | LISURIDE | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL531 | PERGOLIDE | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL59 | DOPAMINE | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 30.3 | nM | 7.52 |
| CHEMBL1621 | PALIPERIDONE | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL2334891 | — | Ki | = | 77.4 | nM | 7.11 |
| CHEMBL726 | FLUPHENAZINE | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL493 | BROMOCRIPTINE | Ki | = | 373.0 | nM | 6.43 |
| CHEMBL487387 | STEPHOLIDINE | Ki | = | 1453.0 | nM | 5.84 |