Assay Detail
Binding
CHEMBL5527118
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to alpha2A adrenergic receptor (unknown origin) assessed as inhibition constant
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Natural Product-Inspired Dopamine Receptor Ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.61 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157138 | LISURIDE | 3.0 | 1 | 8.70 |
| CHEMBL1621 | PALIPERIDONE | 4.0 | 1 | 7.96 |
| CHEMBL493 | BROMOCRIPTINE | 4.0 | 1 | 7.58 |
| CHEMBL531 | PERGOLIDE | 4.0 | 1 | 7.33 |
| CHEMBL726 | FLUPHENAZINE | 4.0 | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157138 | LISURIDE | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1621 | PALIPERIDONE | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL493 | BROMOCRIPTINE | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL531 | PERGOLIDE | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL726 | FLUPHENAZINE | Ki | = | 314.1 | nM | 6.50 |