Assay Detail

CHEMBL5527136

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Functional

Antagonist activity at D2 receptor (unknown origin)

ChEMBL ↗

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Target

D(2) dopamine receptor (CHEMBL217) ↗

Open DB target context

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D(2) dopamine receptor (CHEMBL217) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target D(2) dopamine receptor

CHEMBL217

Anchored from Assay target.

Protein identity D(2) dopamine receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

D(2) dopamine receptor (CHEMBL217) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Natural Product-Inspired Dopamine Receptor Ligands.

Dorogan M, Namballa HK, Harding WW.
J Med Chem (2024) 67 : 12463 -12484
PubMed 39038276 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	5.90	6.28

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL388342	BOLDINE	—	1	6.28
CHEMBL228082	GLAUCINE	—	1	5.52

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL388342	BOLDINE	IC50	=	520.0	nM	6.28
CHEMBL228082	GLAUCINE	IC50	=	3020.0	nM	5.52