Assay Detail
Functional
CHEMBL5527409
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Antiproliferative activity against human NCI-H446 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H446 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Preclinical Candidate AD1058 as a Highly Potent, Selective, and Brain-Penetrant ATR Inhibitor for the Treatment of Advanced Malignancies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.94 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5561233 | — | — | 1 | 6.64 |
| CHEMBL5549943 | — | — | 1 | 6.00 |
| CHEMBL4285417 | CERALASERTIB | 3.0 | 1 | 5.71 |
| CHEMBL2325697 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5561233 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5549943 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL4285417 | CERALASERTIB | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL2325697 | — | IC50 | = | 3900.0 | nM | 5.41 |