Assay Detail
Binding
CHEMBL5527748
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at Gal4-fused human RXRalpha transfected in HEK293T cells incubated for 16 hrs by firefly/renilla based Dual-Glo luciferase assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural Optimization of Oxaprozin for Selective Inverse Nurr1 Agonism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.31 | 6.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5399947 | — | — | 1 | 6.03 |
| CHEMBL5395851 | — | — | 1 | 5.92 |
| CHEMBL5394779 | — | — | 1 | 5.52 |
| CHEMBL5567943 | — | — | 1 | 5.40 |
| CHEMBL5558226 | — | — | 1 | 5.25 |
| CHEMBL5398853 | — | — | 1 | 4.98 |
| CHEMBL5417665 | — | — | 1 | 4.89 |
| CHEMBL5567959 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5399947 | — | EC50 | = | 930.0 | nM | 6.03 |
| CHEMBL5395851 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5394779 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5567943 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5558226 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL5398853 | — | EC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL5417665 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL5567959 | — | EC50 | = | 33000.0 | nM | 4.48 |