Assay Detail
Binding
CHEMBL5527764
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inverse agonist activity at Gal4-fused human full length Nurr1 heterodimer transfected in HEK293T cells cotransfected with pSG5-RXR/pFR-Luc-DR5/pRL-SV40 (DR5) incubated for 12 to 14 hrs by firefly/renilla based Dual-Glo luciferase assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nuclear receptor subfamily 4 group A member 2 (CHEMBL5002) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structural Optimization of Oxaprozin for Selective Inverse Nurr1 Agonism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 4.92 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1071 | OXAPROZIN | 4.0 | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1071 | OXAPROZIN | IC50 | = | 12000.0 | nM | 4.92 |