Assay Detail
Binding
CHEMBL5527768
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inverse agonist activity at human Nur77 (358 to 598 residues) transfected in HEK293T cells incubated for 12 to 14 hrs by firefly/renilla based Dual-Glo luciferase assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nuclear receptor subfamily 4immunitygroup A member 1 (CHEMBL1293229) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structural Optimization of Oxaprozin for Selective Inverse Nurr1 Agonism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 4.80 | 4.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1071 | OXAPROZIN | 4.0 | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1071 | OXAPROZIN | IC50 | = | 16000.0 | nM | 4.80 |