Assay Detail
Binding
CHEMBL5527779
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inverse agonist activity at Gal4-fused human Nurr1 L444F mutant transfected in HEK293T cells incubated for 16 hrs by firefly/renilla based Dual-Glo luciferase assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structural Optimization of Oxaprozin for Selective Inverse Nurr1 Agonism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.09 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5549932 | — | — | 1 | 5.16 |
| CHEMBL331916 | — | — | 1 | 5.10 |
| CHEMBL1071 | OXAPROZIN | 4.0 | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5549932 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL331916 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1071 | OXAPROZIN | IC50 | = | 10000.0 | nM | 5.00 |