Assay Detail
Functional
CHEMBL5528524
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Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of the first PARP-1 and proteasome dual inhibitors to treat breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.89 | 7.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5571547 | — | — | 1 | 7.84 |
| CHEMBL5565652 | — | — | 1 | 7.68 |
| CHEMBL5571367 | — | — | 1 | 7.39 |
| CHEMBL5569313 | — | — | 1 | 7.35 |
| CHEMBL5575779 | — | — | 1 | 7.30 |
| CHEMBL5555633 | — | — | 1 | 7.23 |
| CHEMBL5574533 | — | — | 1 | 7.22 |
| CHEMBL5565731 | — | — | 1 | 7.06 |
| CHEMBL5574128 | — | — | 1 | 6.89 |
| CHEMBL2141296 | IXAZOMIB | 3.0 | 1 | 6.87 |
| CHEMBL5591486 | — | — | 1 | 6.76 |
| CHEMBL5571281 | — | — | 1 | 6.45 |
| CHEMBL5567244 | — | — | 1 | 6.31 |
| CHEMBL5570683 | — | — | 1 | 6.01 |
| CHEMBL521686 | OLAPARIB | 4.0 | 1 | 4.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5571547 | — | IC50 | = | 14.6 | nM | 7.84 |
| CHEMBL5565652 | — | IC50 | = | 20.8 | nM | 7.68 |
| CHEMBL5571367 | — | IC50 | = | 40.8 | nM | 7.39 |
| CHEMBL5569313 | — | IC50 | = | 45.1 | nM | 7.35 |
| CHEMBL5575779 | — | IC50 | = | 49.5 | nM | 7.30 |
| CHEMBL5555633 | — | IC50 | = | 58.6 | nM | 7.23 |
| CHEMBL5574533 | — | IC50 | = | 60.1 | nM | 7.22 |
| CHEMBL5565731 | — | IC50 | = | 87.9 | nM | 7.06 |
| CHEMBL5574128 | — | IC50 | = | 129.9 | nM | 6.89 |
| CHEMBL2141296 | IXAZOMIB | IC50 | = | 135.2 | nM | 6.87 |
| CHEMBL5591486 | — | IC50 | = | 173.6 | nM | 6.76 |
| CHEMBL5571281 | — | IC50 | = | 355.4 | nM | 6.45 |
| CHEMBL5567244 | — | IC50 | = | 493.3 | nM | 6.31 |
| CHEMBL5570683 | — | IC50 | = | 980.3 | nM | 6.01 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 10580.0 | nM | 4.98 |