Assay Detail
Functional
CHEMBL5528525
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Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of the first PARP-1 and proteasome dual inhibitors to treat breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.09 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5591486 | — | — | 1 | 7.68 |
| CHEMBL5574128 | — | — | 1 | 7.55 |
| CHEMBL5571547 | — | — | 1 | 7.53 |
| CHEMBL5575779 | — | — | 1 | 7.51 |
| CHEMBL5565652 | — | — | 1 | 7.43 |
| CHEMBL2141296 | IXAZOMIB | 3.0 | 1 | 7.37 |
| CHEMBL5555633 | — | — | 1 | 7.20 |
| CHEMBL5574533 | — | — | 1 | 7.17 |
| CHEMBL5571367 | — | — | 1 | 7.00 |
| CHEMBL5567244 | — | — | 1 | 6.75 |
| CHEMBL5571281 | — | — | 1 | 6.60 |
| CHEMBL5569313 | — | — | 1 | 6.53 |
| CHEMBL5570683 | — | — | 1 | 6.48 |
| CHEMBL5565731 | — | — | 1 | 6.47 |
| CHEMBL521686 | OLAPARIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5591486 | — | IC50 | = | 20.8 | nM | 7.68 |
| CHEMBL5574128 | — | IC50 | = | 28.1 | nM | 7.55 |
| CHEMBL5571547 | — | IC50 | = | 29.5 | nM | 7.53 |
| CHEMBL5575779 | — | IC50 | = | 31.2 | nM | 7.51 |
| CHEMBL5565652 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL2141296 | IXAZOMIB | IC50 | = | 42.6 | nM | 7.37 |
| CHEMBL5555633 | — | IC50 | = | 63.6 | nM | 7.20 |
| CHEMBL5574533 | — | IC50 | = | 67.6 | nM | 7.17 |
| CHEMBL5571367 | — | IC50 | = | 100.8 | nM | 7.00 |
| CHEMBL5567244 | — | IC50 | = | 178.4 | nM | 6.75 |
| CHEMBL5571281 | — | IC50 | = | 248.9 | nM | 6.60 |
| CHEMBL5569313 | — | IC50 | = | 296.8 | nM | 6.53 |
| CHEMBL5570683 | — | IC50 | = | 328.0 | nM | 6.48 |
| CHEMBL5565731 | — | IC50 | = | 338.2 | nM | 6.47 |
| CHEMBL521686 | OLAPARIB | IC50 | > | 30000.0 | nM | - |