Assay Detail
Functional
CHEMBL5528689
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
An imidazo[1,2-a]pyridine-pyridine derivative potently inhibits FLT3-ITD and FLT3-ITD secondary mutants, including gilteritinib-resistant FLT3-ITD/F691L.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 6.34 | 6.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5573164 | — | — | 1 | 6.94 |
| CHEMBL5566854 | — | — | 1 | 6.92 |
| CHEMBL5592538 | — | — | 1 | 6.88 |
| CHEMBL5574627 | — | — | 1 | 6.68 |
| CHEMBL5567007 | — | — | 1 | 6.66 |
| CHEMBL5589647 | — | — | 1 | 6.58 |
| CHEMBL5571822 | — | — | 1 | 6.56 |
| CHEMBL5569292 | — | — | 1 | 6.16 |
| CHEMBL5571612 | — | — | 1 | 6.13 |
| CHEMBL5573680 | — | — | 1 | 6.05 |
| CHEMBL5570582 | — | — | 1 | 6.04 |
| CHEMBL5563397 | — | — | 1 | 6.03 |
| CHEMBL5568659 | — | — | 1 | 6.03 |
| CHEMBL5557310 | — | — | 1 | 6.02 |
| CHEMBL5595005 | — | — | 1 | 6.01 |
| CHEMBL24828 | VANDETANIB | 4.0 | 1 | 5.81 |
| CHEMBL5575709 | — | — | 1 | - |
| CHEMBL5566186 | — | — | 1 | - |
| CHEMBL5542394 | — | — | 1 | - |
| CHEMBL5592651 | — | — | 1 | - |
| CHEMBL5565983 | — | — | 1 | - |
| CHEMBL5569381 | — | — | 1 | - |
| CHEMBL5569879 | — | — | 1 | - |
| CHEMBL5569052 | — | — | 1 | - |
| CHEMBL5566645 | — | — | 1 | - |
| CHEMBL3301622 | GILTERITINIB | 4.0 | 1 | - |
| CHEMBL5573225 | — | — | 1 | - |
| CHEMBL5575311 | — | — | 1 | - |
| CHEMBL5566699 | — | — | 1 | - |
| CHEMBL5555244 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5573164 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL5566854 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL5592538 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL5574627 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5567007 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL5589647 | — | IC50 | = | 262.0 | nM | 6.58 |
| CHEMBL5571822 | — | IC50 | = | 274.0 | nM | 6.56 |
| CHEMBL5569292 | — | IC50 | = | 688.0 | nM | 6.16 |
| CHEMBL5571612 | — | IC50 | = | 736.0 | nM | 6.13 |
| CHEMBL5573680 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL5570582 | — | IC50 | = | 923.0 | nM | 6.04 |
| CHEMBL5563397 | — | IC50 | = | 924.0 | nM | 6.03 |
| CHEMBL5568659 | — | IC50 | = | 927.0 | nM | 6.03 |
| CHEMBL5557310 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL5595005 | — | IC50 | = | 969.0 | nM | 6.01 |
| CHEMBL24828 | VANDETANIB | IC50 | = | 1535.0 | nM | 5.81 |
| CHEMBL5574518 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5575586 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5573079 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5562812 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5556060 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5575457 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5574019 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5572898 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5571723 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5591269 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5569019 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5590090 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5571391 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5556978 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5555704 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5555244 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5566699 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5575311 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5573225 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3301622 | GILTERITINIB | IC50 | > | 1000.0 | nM | - |
| CHEMBL5566645 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5569052 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5569879 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5569381 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5565983 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5592651 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5542394 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5566186 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5575709 | — | IC50 | > | 1000.0 | nM | - |