Assay Detail
Binding
CHEMBL5529140
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Keap1-Nrf2 protein-protein interaction (unknown origin) by TR-FRET assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Structural modification of C2-substituents on 1,4-bis(arylsulfonamido)benzene or naphthalene-N,N'-diacetic acid derivatives as potent inhibitors of the Keap1-Nrf2 protein-protein interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.39 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5571025 | — | — | 1 | 7.72 |
| CHEMBL5570595 | — | — | 1 | 7.65 |
| CHEMBL3237245 | — | — | 1 | 7.54 |
| CHEMBL5595521 | — | — | 1 | 7.26 |
| CHEMBL5567314 | — | — | 1 | 7.14 |
| CHEMBL5556087 | — | — | 1 | 7.04 |
| CHEMBL5181633 | — | — | 1 | - |
| CHEMBL5590315 | — | — | 1 | - |
| CHEMBL5557583 | — | — | 1 | - |
| CHEMBL5572451 | — | — | 1 | - |
| CHEMBL5573249 | — | — | 1 | - |
| CHEMBL5594768 | — | — | 1 | - |
| CHEMBL5593633 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5571025 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5570595 | — | IC50 | = | 22.3 | nM | 7.65 |
| CHEMBL3237245 | — | IC50 | = | 28.5 | nM | 7.54 |
| CHEMBL5595521 | — | IC50 | = | 54.3 | nM | 7.26 |
| CHEMBL5567314 | — | IC50 | = | 72.2 | nM | 7.14 |
| CHEMBL5556087 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL5181633 | — | IC50 | - | — | - | |
| CHEMBL5590315 | — | IC50 | - | — | - | |
| CHEMBL5557583 | — | IC50 | - | — | - | |
| CHEMBL5572451 | — | IC50 | - | — | - | |
| CHEMBL5573249 | — | IC50 | - | — | - | |
| CHEMBL5594768 | — | IC50 | - | — | - | |
| CHEMBL5593633 | — | IC50 | - | — | - |