Assay Detail
Functional
CHEMBL5529522
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Antiviral activity against Influenza A virus A/PR/8/34 (H1N1) infected in MDCK cells assessed as reduction in virus-induced cytopathic effect incubated for 5 days by CCK8 based microplate spectrophotometric analysis
26
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Macrocyclic Influenza Cap-Dependent Endonuclease Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 7.78 | 8.68 |
| EC90 | 13 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297215 | BALOXAVIR | 2.0 | 2 | 8.68 |
| CHEMBL5570012 | — | — | 2 | 8.14 |
| CHEMBL5573359 | — | — | 2 | 7.96 |
| CHEMBL5557564 | — | — | 2 | 7.96 |
| CHEMBL5573596 | — | — | 2 | 7.85 |
| CHEMBL5569095 | — | — | 2 | 7.85 |
| CHEMBL5575494 | — | — | 2 | 7.60 |
| CHEMBL5571483 | — | — | 2 | 7.30 |
| CHEMBL5549989 | — | — | 2 | 7.28 |
| CHEMBL5575392 | — | — | 2 | 7.19 |
| CHEMBL5568682 | — | — | 2 | - |
| CHEMBL5567085 | — | — | 2 | - |
| CHEMBL5571971 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297215 | BALOXAVIR | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL5570012 | — | EC50 | = | 7.2 | nM | 8.14 |
| CHEMBL5557564 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5573359 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5573596 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5569095 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5575494 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5571483 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5549989 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL5575392 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL5568682 | — | EC50 | > | 500.0 | nM | - |
| CHEMBL5567085 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5573596 | — | EC90 | = | 26.0 | nM | - |
| CHEMBL5568682 | — | EC90 | > | 500.0 | nM | - |
| CHEMBL5567085 | — | EC90 | > | 1000.0 | nM | - |
| CHEMBL4297215 | BALOXAVIR | EC90 | = | 4.6 | nM | - |
| CHEMBL5575392 | — | EC90 | = | 120.0 | nM | - |
| CHEMBL5549989 | — | EC90 | = | 105.0 | nM | - |
| CHEMBL5571971 | — | EC50 | > | 500.0 | nM | - |
| CHEMBL5570012 | — | EC90 | = | 12.0 | nM | - |
| CHEMBL5571971 | — | EC90 | > | 500.0 | nM | - |
| CHEMBL5557564 | — | EC90 | = | 18.0 | nM | - |
| CHEMBL5573359 | — | EC90 | = | 16.0 | nM | - |
| CHEMBL5571483 | — | EC90 | = | 93.0 | nM | - |
| CHEMBL5569095 | — | EC90 | = | 24.0 | nM | - |
| CHEMBL5575494 | — | EC90 | = | 42.0 | nM | - |