Assay Detail
Functional
CHEMBL5529523
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Antiviral activity against Influenza A virus A/PR/8/34 PA-I38T infected in MDCK cells assessed as reduction in virus-induced cytopathic effect incubated for 5 days by CCK8 based microplate spectrophotometric analysis
26
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Macrocyclic Influenza Cap-Dependent Endonuclease Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 6.74 | 7.18 |
| EC90 | 13 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5570012 | — | — | 2 | 7.18 |
| CHEMBL5573359 | — | — | 2 | 7.10 |
| CHEMBL4297215 | BALOXAVIR | 2.0 | 2 | 6.85 |
| CHEMBL5557564 | — | — | 2 | 6.78 |
| CHEMBL5569095 | — | — | 2 | 6.71 |
| CHEMBL5575494 | — | — | 2 | 6.68 |
| CHEMBL5573596 | — | — | 2 | 6.67 |
| CHEMBL5549989 | — | — | 2 | 6.36 |
| CHEMBL5571483 | — | — | 2 | 6.29 |
| CHEMBL5568682 | — | — | 2 | - |
| CHEMBL5567085 | — | — | 2 | - |
| CHEMBL5575392 | — | — | 2 | - |
| CHEMBL5571971 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5570012 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL5573359 | — | EC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4297215 | BALOXAVIR | EC50 | = | 142.0 | nM | 6.85 |
| CHEMBL5557564 | — | EC50 | = | 166.0 | nM | 6.78 |
| CHEMBL5569095 | — | EC50 | = | 193.0 | nM | 6.71 |
| CHEMBL5575494 | — | EC50 | = | 211.0 | nM | 6.68 |
| CHEMBL5573596 | — | EC50 | = | 214.0 | nM | 6.67 |
| CHEMBL5549989 | — | EC50 | = | 435.0 | nM | 6.36 |
| CHEMBL5571483 | — | EC50 | = | 512.0 | nM | 6.29 |
| CHEMBL5568682 | — | EC50 | - | — | - | |
| CHEMBL5567085 | — | EC50 | - | — | - | |
| CHEMBL5573596 | — | EC90 | = | 336.0 | nM | - |
| CHEMBL5568682 | — | EC90 | - | — | - | |
| CHEMBL5567085 | — | EC90 | - | — | - | |
| CHEMBL4297215 | BALOXAVIR | EC90 | = | 232.0 | nM | - |
| CHEMBL5575392 | — | EC50 | - | — | - | |
| CHEMBL5575392 | — | EC90 | - | — | - | |
| CHEMBL5549989 | — | EC90 | = | 675.0 | nM | - |
| CHEMBL5570012 | — | EC90 | = | 113.0 | nM | - |
| CHEMBL5571971 | — | EC90 | - | — | - | |
| CHEMBL5557564 | — | EC90 | = | 344.0 | nM | - |
| CHEMBL5573359 | — | EC90 | = | 123.0 | nM | - |
| CHEMBL5571971 | — | EC50 | - | — | - | |
| CHEMBL5575494 | — | EC90 | = | 393.0 | nM | - |
| CHEMBL5571483 | — | EC90 | = | 795.0 | nM | - |
| CHEMBL5569095 | — | EC90 | = | 370.0 | nM | - |