Assay Detail
Functional
CHEMBL5529529
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Antiviral activity against Influenza B virus B/Lee/40 infected in MDCK cells assessed as reduction in virus-induced cytopathic effect incubated for 5 days by CCK8 based microplate spectrophotometric analysis
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza B virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Macrocyclic Influenza Cap-Dependent Endonuclease Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC90 | 2 | - | - |
| EC50 | 2 | 7.88 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5570012 | — | — | 2 | 8.07 |
| CHEMBL4297215 | BALOXAVIR | 2.0 | 2 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5570012 | — | EC50 | = | 8.5 | nM | 8.07 |
| CHEMBL4297215 | BALOXAVIR | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4297215 | BALOXAVIR | EC90 | = | 43.0 | nM | - |
| CHEMBL5570012 | — | EC90 | = | 16.0 | nM | - |