Assay Detail
Binding
CHEMBL5529686
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mTOR in human MDA-MB-468 cells incubated for 2.5 hrs by Alexa Fluor 488 staining based fluorescence analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-468 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of Novel, Selective Ataxia-Telangiectasia Mutated Kinase Inhibitors with the Ability to Penetrate the Blood-Brain Barrier: The Discovery of AZD1390.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.90 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5575600 | — | — | 1 | 6.30 |
| CHEMBL3960662 | — | — | 1 | 5.90 |
| CHEMBL5555756 | — | — | 1 | 5.50 |
| CHEMBL5566946 | — | — | 1 | - |
| CHEMBL4594429 | AZD-1390 | 1.0 | 1 | - |
| CHEMBL5572255 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5575600 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL3960662 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL5555756 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL5566946 | — | IC50 | > | 31622.78 | nM | - |
| CHEMBL4594429 | AZD-1390 | IC50 | > | 15848.93 | nM | - |
| CHEMBL5572255 | — | IC50 | > | 1258.93 | nM | - |