Assay Detail
Functional
CHEMBL5529893
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human SW837 cells incubated for 6 days in presence of 1 uM (2S,4R)-1-((S)-2-(5-((4-(((R)-1-(3-amino-5-(trifluoromethyl)phenyl)ethyl)amino)-7-methoxy-2-methylquinazolin-6-yl)oxy)pentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide by CCK8 assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW837 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A Potent SOS1 PROTAC Degrader with Synergistic Efficacy in Combination with KRAS<sup>G12C</sup> Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.52 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4535757 | SOTORASIB | 4.0 | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4535757 | SOTORASIB | IC50 | = | 3.0 | nM | 8.52 |