Assay Detail
Binding
CHEMBL5529917
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to BTK/CRBN (unknown origin) assessed as ternary complex formation measured after 60 mins incubation by HTRF assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MINO |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Protein cereblon/Tyrosine-protein kinase BTK (CHEMBL4523704) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Discovery of Novel Potent and Fast BTK PROTACs for the Treatment of Osteoclasts-Related Inflammatory Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 8.47 | 8.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5583871 | — | — | 1 | 8.56 |
| CHEMBL5583805 | — | — | 1 | 8.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5583871 | — | EC50 | = | 2.741 | nM | 8.56 |
| CHEMBL5583805 | — | EC50 | = | 4.28 | nM | 8.37 |