Assay Detail
Functional
CHEMBL5530255
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Antiproliferative activity against human A549 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Isoquinoline Analogues as Dual Tubulin Polymerization/V-ATPase Inhibitors with Immunogenic Cell Death Induction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.17 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.40 |
| CHEMBL5574245 | — | — | 1 | 7.05 |
| CHEMBL5565140 | — | — | 1 | 6.80 |
| CHEMBL5555583 | — | — | 1 | 6.75 |
| CHEMBL5573075 | — | — | 1 | 6.70 |
| CHEMBL5573228 | — | — | 1 | 6.60 |
| CHEMBL5574643 | — | — | 1 | 6.43 |
| CHEMBL5571857 | — | — | 1 | 6.08 |
| CHEMBL221190 | DIPHYLLIN | — | 1 | 6.05 |
| CHEMBL5565046 | — | — | 1 | 5.90 |
| CHEMBL5592218 | — | — | 1 | 5.86 |
| CHEMBL5572126 | — | — | 1 | 5.82 |
| CHEMBL5595877 | — | — | 1 | 5.76 |
| CHEMBL5575366 | — | — | 1 | 5.73 |
| CHEMBL5569133 | — | — | 1 | 5.70 |
| CHEMBL5563314 | — | — | 1 | 5.67 |
| CHEMBL5571090 | — | — | 1 | 5.53 |
| CHEMBL5557309 | — | — | 1 | 5.25 |
| CHEMBL5563509 | — | — | 1 | - |
| CHEMBL5568977 | — | — | 1 | - |
| CHEMBL5557536 | — | — | 1 | - |
| CHEMBL5574141 | — | — | 1 | - |
| CHEMBL5573142 | — | — | 1 | - |
| CHEMBL5567515 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5574245 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5565140 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5555583 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5573075 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5573228 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5574643 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5571857 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL221190 | DIPHYLLIN | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL5565046 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL5592218 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL5572126 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL5595877 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL5575366 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL5569133 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL5563314 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL5571090 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL5557309 | — | IC50 | = | 5560.0 | nM | 5.25 |
| CHEMBL5563509 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5568977 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5557536 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5574141 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5573142 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5567515 | — | IC50 | > | 10000.0 | nM | - |