Assay Detail
Functional
CHEMBL5530258
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Isoquinoline Analogues as Dual Tubulin Polymerization/V-ATPase Inhibitors with Immunogenic Cell Death Induction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.14 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 6.92 |
| CHEMBL5574245 | — | — | 1 | 6.89 |
| CHEMBL5565140 | — | — | 1 | 6.68 |
| CHEMBL5555583 | — | — | 1 | 6.52 |
| CHEMBL5573075 | — | — | 1 | 6.40 |
| CHEMBL5574643 | — | — | 1 | 6.32 |
| CHEMBL5563314 | — | — | 1 | 6.14 |
| CHEMBL5575366 | — | — | 1 | 6.12 |
| CHEMBL5573228 | — | — | 1 | 6.06 |
| CHEMBL5571857 | — | — | 1 | 5.90 |
| CHEMBL5569133 | — | — | 1 | 5.88 |
| CHEMBL5565046 | — | — | 1 | 5.87 |
| CHEMBL5595877 | — | — | 1 | 5.80 |
| CHEMBL221190 | DIPHYLLIN | — | 1 | 5.64 |
| CHEMBL5592218 | — | — | 1 | 5.62 |
| CHEMBL5572126 | — | — | 1 | 5.49 |
| CHEMBL5571090 | — | — | 1 | - |
| CHEMBL5557309 | — | — | 1 | - |
| CHEMBL5568977 | — | — | 1 | - |
| CHEMBL5563509 | — | — | 1 | - |
| CHEMBL5557536 | — | — | 1 | - |
| CHEMBL5574141 | — | — | 1 | - |
| CHEMBL5573142 | — | — | 1 | - |
| CHEMBL5567515 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5574245 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5565140 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5555583 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5573075 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5574643 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL5563314 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL5575366 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5573228 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL5571857 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL5569133 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL5565046 | — | IC50 | = | 1352.0 | nM | 5.87 |
| CHEMBL5595877 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL221190 | DIPHYLLIN | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL5592218 | — | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL5572126 | — | IC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL5571090 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5557309 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5568977 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5563509 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5557536 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5574141 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5573142 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5567515 | — | IC50 | > | 10000.0 | nM | - |