Assay Detail
Binding
CHEMBL5530428
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant ADAMTS7 (unknown origin) using HiLyteFluor-488 DELSSMVLELRGLRT-K(QXL520)-E-NH2 as substrate incubated for 120 mins by FRET assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
A disintegrin and metalloproteinase with thrombospondin motifs 7 (CHEMBL5724789) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
BAY-9835: Discovery of the First Orally Bioavailable ADAMTS7 Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 7.34 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5571635 | — | — | 1 | 8.52 |
| CHEMBL5574355 | — | — | 1 | 8.52 |
| CHEMBL5595087 | — | — | 1 | 8.30 |
| CHEMBL5567356 | — | — | 1 | 8.22 |
| CHEMBL5572837 | — | — | 1 | 8.10 |
| CHEMBL5589887 | — | — | 1 | 8.05 |
| CHEMBL5590012 | — | — | 1 | 8.00 |
| CHEMBL5082898 | — | — | 1 | 7.89 |
| CHEMBL5574922 | — | — | 1 | 7.85 |
| CHEMBL5592187 | — | — | 1 | 7.82 |
| CHEMBL5563780 | — | — | 1 | 7.80 |
| CHEMBL5568936 | — | — | 1 | 7.75 |
| CHEMBL5592274 | — | — | 1 | 7.72 |
| CHEMBL5595652 | — | — | 1 | 7.72 |
| CHEMBL5086874 | — | — | 1 | 7.68 |
| CHEMBL5092149 | — | — | 1 | 7.58 |
| CHEMBL5077651 | — | — | 1 | 7.58 |
| CHEMBL5562698 | — | — | 1 | 7.54 |
| CHEMBL5591976 | — | — | 1 | 7.34 |
| CHEMBL5085716 | — | — | 1 | 7.33 |
| CHEMBL5570826 | — | — | 1 | 7.33 |
| CHEMBL5569538 | — | — | 1 | 7.22 |
| CHEMBL5085514 | — | — | 1 | 7.21 |
| CHEMBL5572305 | — | — | 1 | 7.14 |
| CHEMBL5569748 | — | — | 1 | 7.10 |
| CHEMBL5567489 | — | — | 1 | 7.00 |
| CHEMBL5086082 | — | — | 1 | 6.94 |
| CHEMBL5076179 | — | — | 1 | 6.89 |
| CHEMBL5073508 | — | — | 1 | 6.75 |
| CHEMBL5082246 | — | — | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5571635 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5574355 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5595087 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5567356 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5572837 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5589887 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5590012 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5082898 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5574922 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5592187 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5563780 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5568936 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5592274 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5595652 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5086874 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5092149 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5077651 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5562698 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5591976 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL5570826 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL5085716 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL5569538 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5085514 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL5572305 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL5569748 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL5567489 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL5086082 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL5076179 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL5073508 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5082246 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5593541 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5572058 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL5570775 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL5590568 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL5574157 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL5575127 | — | IC50 | = | 2300.0 | nM | 5.64 |