Assay Detail
Functional
CHEMBL5530494
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Antiproliferative activity against FGFR4 independent human NCI-H1299 cells assessed as inhibition of cell growth
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.01 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5218465 | — | — | 1 | 5.89 |
| CHEMBL5571014 | — | — | 1 | 5.62 |
| CHEMBL5583995 | — | — | 1 | 5.46 |
| CHEMBL5573605 | — | — | 1 | 5.37 |
| CHEMBL5566209 | — | — | 1 | 5.23 |
| CHEMBL5557003 | — | — | 1 | 4.94 |
| CHEMBL5573735 | — | — | 1 | 4.93 |
| CHEMBL5584172 | — | — | 1 | 4.89 |
| CHEMBL3908979 | FGF401 | 2.0 | 1 | 4.82 |
| CHEMBL5568669 | — | — | 1 | 4.69 |
| CHEMBL5574215 | — | — | 1 | 4.63 |
| CHEMBL5572973 | — | — | 1 | 4.44 |
| CHEMBL5543045 | — | — | 1 | 4.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5218465 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5571014 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5583995 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL5573605 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL5566209 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL5557003 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL5573735 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL5584172 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL3908979 | FGF401 | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL5568669 | — | IC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL5574215 | — | IC50 | = | 23600.0 | nM | 4.63 |
| CHEMBL5572973 | — | IC50 | = | 36600.0 | nM | 4.44 |
| CHEMBL5543045 | — | IC50 | = | 56000.0 | nM | 4.25 |