Assay Detail
Functional
CHEMBL5531297
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against mouse 4T1 cells cultured as 2D cells assessed as inhibition of cell growth incubated for 48 hrs by alamar blue assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | 4T1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Mechanistic Investigation of Thiazole-Based Pyruvate Kinase M2 Inhibitor Causing Tumor Regression in Triple-Negative Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.74 | 5.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL554 | LAPATINIB | 4.0 | 1 | 5.11 |
| CHEMBL5569778 | — | — | 1 | 4.84 |
| CHEMBL5590701 | — | — | 1 | 4.83 |
| CHEMBL5565674 | — | — | 1 | 4.68 |
| CHEMBL5574969 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL554 | LAPATINIB | IC50 | = | 7860.0 | nM | 5.11 |
| CHEMBL5569778 | — | IC50 | = | 14380.0 | nM | 4.84 |
| CHEMBL5590701 | — | IC50 | = | 14820.0 | nM | 4.83 |
| CHEMBL5565674 | — | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL5574969 | — | IC50 | = | 60060.0 | nM | 4.22 |