Assay Detail
Functional
CHEMBL5531433
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at GPR183 (unknown origin) transfected in HEK293 cells cotransfected with CRE-luciferase plasmid assessed as restoration of luciferase activity preincubated for 30 mins followed by 7alpha,25-dihydroxycholesterol induction and measured after 4 hrs by dual luciferase assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Highly Potent Oxysterol Receptor GPR183 Antagonist Bearing the Benzo[<i>d</i>]thiazole Structural Motif for the Treatment of Inflammatory Bowel Disease (IBD).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.74 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5567610 | — | — | 1 | 8.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5567610 | — | IC50 | = | 1.83 | nM | 8.74 |