Assay Detail
Functional
CHEMBL5531436
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at GPR183 (unknown origin) transfected in HEK293 cells co-expressing LgBiT-fused SmBiT-beta-arrestin assessed as reduction in beta-arrestin recruitment using nanoluciferase as substrate incubated for 30 mins by bioluminescence based NanoBiT assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Highly Potent Oxysterol Receptor GPR183 Antagonist Bearing the Benzo[<i>d</i>]thiazole Structural Motif for the Treatment of Inflammatory Bowel Disease (IBD).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 9.06 | 9.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5567610 | — | — | 1 | 9.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5567610 | — | IC50 | = | 0.88 | nM | 9.06 |