Assay Detail
Binding
CHEMBL5531599
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human MAO-B expressed in baculovirus infected BTI-TN-5B1-4 insect cells using kynuramine as substrate incubated for 10 10 mins by spectrophotometric assay
63
Total Activities
63
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BTI-TN-5B1-4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dual Inhibitors of Brain Carbonic Anhydrases and Monoamine Oxidase-B Efficiently Protect against Amyloid-β-Induced Neuronal Toxicity, Oxidative Stress, and Mitochondrial Dysfunction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 63 | 6.61 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL145781 | 7-BENZYLOXYCOUMARIN | — | 1 | 8.42 |
| CHEMBL5583585 | — | — | 1 | 8.17 |
| CHEMBL5565316 | — | — | 1 | 8.15 |
| CHEMBL5571218 | — | — | 1 | 8.10 |
| CHEMBL5566534 | — | — | 1 | 8.04 |
| CHEMBL5568690 | — | — | 1 | 7.95 |
| CHEMBL5570880 | — | — | 1 | 7.95 |
| CHEMBL5572513 | — | — | 1 | 7.83 |
| CHEMBL5565484 | — | — | 1 | 7.49 |
| CHEMBL5563085 | — | — | 1 | 7.45 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 7.32 |
| CHEMBL5562537 | — | — | 1 | 7.29 |
| CHEMBL5573087 | — | — | 1 | 7.20 |
| CHEMBL5575945 | — | — | 1 | 7.13 |
| CHEMBL5567576 | — | — | 1 | 7.09 |
| CHEMBL5556627 | — | — | 1 | 6.95 |
| CHEMBL5575065 | — | — | 1 | 6.81 |
| CHEMBL5571185 | — | — | 1 | 6.68 |
| CHEMBL5563200 | — | — | 1 | 6.49 |
| CHEMBL5575196 | — | — | 1 | 6.38 |
| CHEMBL5569288 | — | — | 1 | 6.17 |
| CHEMBL5563290 | — | — | 1 | 6.17 |
| CHEMBL5570926 | — | — | 1 | 6.15 |
| CHEMBL5573918 | — | — | 1 | 6.11 |
| CHEMBL5583624 | — | — | 1 | 6.07 |
| CHEMBL5575430 | — | — | 1 | 6.04 |
| CHEMBL5570999 | — | — | 1 | 5.87 |
| CHEMBL5570372 | — | — | 1 | 5.76 |
| CHEMBL5575791 | — | — | 1 | 5.76 |
| CHEMBL5565616 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL145781 | 7-BENZYLOXYCOUMARIN | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL5583585 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL5565316 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5571218 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL5566534 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL5568690 | — | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL5570880 | — | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL5572513 | — | IC50 | = | 14.9 | nM | 7.83 |
| CHEMBL5565484 | — | IC50 | = | 32.6 | nM | 7.49 |
| CHEMBL5563085 | — | IC50 | = | 35.6 | nM | 7.45 |
| CHEMBL972 | SELEGILINE | IC50 | = | 47.6 | nM | 7.32 |
| CHEMBL5562537 | — | IC50 | = | 51.9 | nM | 7.29 |
| CHEMBL5573087 | — | IC50 | = | 63.4 | nM | 7.20 |
| CHEMBL5575945 | — | IC50 | = | 73.4 | nM | 7.13 |
| CHEMBL5567576 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL5556627 | — | IC50 | = | 111.2 | nM | 6.95 |
| CHEMBL5575065 | — | IC50 | = | 155.6 | nM | 6.81 |
| CHEMBL5571185 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL5563200 | — | IC50 | = | 324.0 | nM | 6.49 |
| CHEMBL5575196 | — | IC50 | = | 413.4 | nM | 6.38 |
| CHEMBL5569288 | — | IC50 | = | 667.8 | nM | 6.17 |
| CHEMBL5563290 | — | IC50 | = | 670.2 | nM | 6.17 |
| CHEMBL5570926 | — | IC50 | = | 702.0 | nM | 6.15 |
| CHEMBL5573918 | — | IC50 | = | 783.0 | nM | 6.11 |
| CHEMBL5583624 | — | IC50 | = | 852.8 | nM | 6.07 |
| CHEMBL5575430 | — | IC50 | = | 912.4 | nM | 6.04 |
| CHEMBL5570999 | — | IC50 | = | 1336.0 | nM | 5.87 |
| CHEMBL5570372 | — | IC50 | = | 1744.0 | nM | 5.76 |
| CHEMBL5575791 | — | IC50 | = | 1739.0 | nM | 5.76 |
| CHEMBL5565616 | — | IC50 | = | 2273.0 | nM | 5.64 |
| CHEMBL8706 | CLORGILINE | IC50 | = | 2501.0 | nM | 5.60 |
| CHEMBL5589767 | — | IC50 | = | 3253.0 | nM | 5.49 |
| CHEMBL5571767 | — | IC50 | = | 3876.0 | nM | 5.41 |
| CHEMBL5574490 | — | IC50 | = | 3936.0 | nM | 5.41 |
| CHEMBL5572092 | — | IC50 | = | 4751.0 | nM | 5.32 |
| CHEMBL5593900 | — | IC50 | = | 7382.0 | nM | 5.13 |
| CHEMBL5571128 | — | IC50 | = | 7868.0 | nM | 5.10 |
| CHEMBL5569915 | — | IC50 | = | 10850.0 | nM | 4.96 |
| CHEMBL5572277 | — | IC50 | - | — | - | |
| CHEMBL5571315 | — | IC50 | - | — | - | |
| CHEMBL5570409 | — | IC50 | - | — | - | |
| CHEMBL5564061 | — | IC50 | - | — | - | |
| CHEMBL5572204 | — | IC50 | - | — | - | |
| CHEMBL23174 | — | IC50 | - | — | - | |
| CHEMBL5564140 | — | IC50 | - | — | - | |
| CHEMBL5570336 | — | IC50 | - | — | - | |
| CHEMBL5567392 | — | IC50 | - | — | - | |
| CHEMBL5591906 | — | IC50 | - | — | - | |
| CHEMBL5564532 | — | IC50 | - | — | - | |
| CHEMBL5583649 | — | IC50 | - | — | - |