Assay Detail
Binding
CHEMBL5531861
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of RET V804M mutant (unknown origin) by DiscoverX KINOMEscan assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Proto-oncogene tyrosine-protein kinase receptor Ret (CHEMBL2041) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Unraveling the Promise of RET Inhibitors in Precision Cancer Therapy by Targeting RET Mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.85 | 7.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3735648 | — | — | 1 | 7.98 |
| CHEMBL3735401 | — | — | 1 | 7.92 |
| CHEMBL5593687 | — | — | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3735648 | — | IC50 | = | 10.4 | nM | 7.98 |
| CHEMBL3735401 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5593687 | — | IC50 | = | 23.0 | nM | 7.64 |