Assay Detail
Functional
CHEMBL5533171
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Antiplasmodial activity against CQ-resistant Plasmodium falciparum FCR-3/Gambia subline F-86 infected in erythrocytes assessed as parasite growth inhibition incubated for 24 hrs by [3H]-hypoxanthine incorporation assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Cell Type | Erythrocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Current development of 1,2,3-triazole derived potential antimalarial scaffolds: Structure- activity relationship (SAR) and bioactive compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.36 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1172285 | — | — | 1 | 8.89 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.85 |
| CHEMBL1171354 | — | — | 1 | 8.60 |
| CHEMBL5570647 | — | — | 1 | 8.43 |
| CHEMBL1171355 | — | — | 1 | 8.38 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1172285 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1171354 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL5570647 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL1171355 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 101.0 | nM | 7.00 |