Assay Detail
Binding
CHEMBL5533408
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tau phosphorylation (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Microtubule-associated protein tau (CHEMBL1293224) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting protein kinases for the treatment of Alzheimer's disease: Recent progress and future perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.25 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5419652 | — | — | 1 | 8.00 |
| CHEMBL5404581 | — | — | 1 | 7.92 |
| CHEMBL5413819 | — | — | 1 | 7.31 |
| CHEMBL5270781 | — | — | 1 | 7.24 |
| CHEMBL5278465 | — | — | 1 | 6.70 |
| CHEMBL5173945 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5419652 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5404581 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5413819 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL5270781 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL5278465 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5173945 | — | IC50 | = | 466.0 | nM | 6.33 |